Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 27;8:11344. doi: 10.1038/s41598-018-29341-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Nitric oxide synthase inhibition blocks delayed blood-brain barrier disruption after blast. (a) At 72 h after 2X blast, a significant increase in ¹⁴C-sucrose, (b) and ^99mTc-albumin was measured in whole brains compared to sham controls treated with INDO (5 mg/kg; ip). (a) No significant differences in ¹⁴C-sucrose, (b) or ^99mTc-albumin were observed when INDO was administered after blast. (c) A significant increase in ¹⁴C-sucrose, (d) and ^99mTc-albumin was also observed in whole brain at 72 h after 2X blast compared to L-NAME treated sham controls. (c) L-NAME administration (10 mg/kg; ip) significantly attenuated a blast-induced increase in ¹⁴C-sucrose, (d) and ^99mTc-albumin. One-way ANOVA post hoc Newman-Keul’s. Values represent mean ± SEM; n = 5. (*p ≤ 0.05 vs sham + L-NAME; ^#p ≤ 0.05 vs blast + vehicle; **p ≤ 0.01 vs sham + INDO).