Table 1.
Brain region | 0.25 h (n = 5) | 3 h (n = 12) | 24 h (n = 11) | 72 h (n = 13) |
---|---|---|---|---|
Frontal cortex | 104 ± 17*** | 33 ± 12* | 30 ± 13 | 33 ± 12* |
Occipital cortex | 70 ± 16*** | 40 ± 11** | 31 ± 12* | 22 ± 11 |
Parietal cortex | 90 ± 17*** | 43 ± 12** | 40 ± 13* | 29 ± 12 |
Striatum | 30 ± 23 | 20 ± 17 | 33 ± 17 | 13 ± 16 |
Midbrain | 82 ± 16*** | 27 ± 12 | 27 ± 12 | 23 ± 11 |
Thalamus | 17 ± 16 | 10 ± 12 | 27 ± 12 | 34 ± 11* |
Cerebellum | 48 ± 15* | 21 ± 11 | 26 ± 12 | 27 ± 11 |
Pons-medulla | 139 ± 21*** | 54 ± 15** | 44 ± 15* | 38 ± 15* |
Hippocampus | 53 ± 15** | 06 ± 11 | 18 ± 11 | 28 ± 10* |
Hypothalamus | 66 ± 21* | 12 ± 15 | 15 ± 16 | 23 ± 15 |
Whole Brain | 87 ± 15*** | 34 ± 11* | 36 ± 11* | 28 ± 11* |
Blood-brain barrier (BBB); mild traumatic brain injury (mTBI). Values represent mean difference ± SEM normalized to sham control animals (n = 22). One-way ANOVA; post-hoc Dunnett’s; *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001.