Table 1.

Temporal profile of regional BBB permeability to ¹⁴C-sucrose after 2X blast mTBI.

Brain region	0.25 h (n = 5)	3 h (n = 12)	24 h (n = 11)	72 h (n = 13)
Frontal cortex	104 ± 17***	33 ± 12*	30 ± 13	33 ± 12*
Occipital cortex	70 ± 16***	40 ± 11**	31 ± 12*	22 ± 11
Parietal cortex	90 ± 17***	43 ± 12**	40 ± 13*	29 ± 12
Striatum	30 ± 23	20 ± 17	33 ± 17	13 ± 16
Midbrain	82 ± 16***	27 ± 12	27 ± 12	23 ± 11
Thalamus	17 ± 16	10 ± 12	27 ± 12	34 ± 11*
Cerebellum	48 ± 15*	21 ± 11	26 ± 12	27 ± 11
Pons-medulla	139 ± 21***	54 ± 15**	44 ± 15*	38 ± 15*
Hippocampus	53 ± 15**	06 ± 11	18 ± 11	28 ± 10*
Hypothalamus	66 ± 21*	12 ± 15	15 ± 16	23 ± 15
Whole Brain	87 ± 15***	34 ± 11*	36 ± 11*	28 ± 11*

Blood-brain barrier (BBB); mild traumatic brain injury (mTBI). Values represent mean difference ± SEM normalized to sham control animals (n = 22). One-way ANOVA; post-hoc Dunnett’s; *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001.