Table 2.
Temporal profile of regional BBB permeability to 99mTc-albumin after 2X blast mTBI.
| Brain region | 0.25 h (n = 5) | 3 h (n = 12) | 24 h (n = 11) | 72 h (n = 13) |
|---|---|---|---|---|
| Frontal cortex | 289 ± 77*** | 59 ± 56 | −18 ± 57 | 148 ± 54* |
| Occipital cortex | 69 ± 56*** | 73 ± 41 | −21 ± 42 | 10 ± 39 |
| Parietal cortex | 129 ± 58*** | 62 ± 42 | −09 ± 43 | 65 ± 41 |
| Striatum | 29 ± 61 | −19 ± 44 | −24 ± 47 | −12 ± 43 |
| Midbrain | 69 ± 56*** | 73 ± 41 | −21 ± 42 | 10 ± 40 |
| Thalamus | 16 ± 79 | 107 ± 57 | 17 ± 59 | 153 ± 55* |
| Cerebellum | 48 ± 35* | 16 ± 25 | −20 ± 26 | 29 ± 24 |
| Pons-medulla | 120 ± 41*** | 57 ± 30 | 11 ± 30 | 88 ± 29* |
| Hippocampus | 203 ± 72** | −31 ± 52 | −27 ± 54 | 144 ± 51* |
| Hypothalamus | 66 ± 73* | 18 ± 53 | −18 ± 55 | 59 ± 52 |
| Whole Brain | 150 ± 36*** | 30 ± 26 | −10 ± 27 | 75 ± 26* |
Blood-brain barrier (BBB); mild traumatic brain injury (mTBI). Values represent mean difference ± SEM normalized to sham control animals (n = 22). One-way ANOVA; post-hoc Dunnett’s; *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001.