Figure 1.

Schematic representation of three CPT nanoparticle scaffolds prepared and used in this study. In case of CPT + PEG, the lipid chain of DSPE‐PEG is expected to noncovalently associate with the hydrophobic surface of CPT as shown in the schematic. In case of CPT‐PEG, two configurations are likely; the amine group in DSPE‐PEG‐amine is chemically conjugated to the surface of CPT, thus exposing the lipid chain outside. DSPE‐PEG‐amine may also fold due to hydrophobic interactions between the lipid chain and hydrophobic CPT surface leading to anchoring of the lipid chain on the CPT surface thus exposing PEG in a loop. For CPT + PEG‐FA, the DSPE‐PEG‐FA is expected to anchor on CPT by its hydrophobic tail, thus exposing FA outwards