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. 2018 Jul 27;8:11314. doi: 10.1038/s41598-018-29617-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of the ulcer size change following MSC sheet endoscopic transplantation in electrocoagulation model. (a) Cell sheets were transplanted onto the ulcer sites by CELLSHIFTER. The yellow line points to the ulcer site. The yellow arrow indicates the covered MSC sheets by CELLSHIFTER (left panel D0). Evaluation of colonic ulcer size. The maximum opening width of the endoscopic forceps used in the transplantation and the basic length of the forceps wire node (right panel D1). (b) Representative histological analysis based on the transplantation success. The red arrow indicates the positive signal of EGFP by immunohistochemistry. (c,d) Success rate and adhesion score of the electrocoagulation ulcer model. (e) The changes in ulcer size before and after transplantation (±SEM n = 8, each). *P < 0.05. (f) A comparison of the ulcer size changes after transplantation day (D0) between 1 day after transplant (D1) (±SEM n = 8, each) **P < 0.01. Con; only electrocoagulation, Sham; transplanted without MSC sheets, AD-MSC; AD-MSC sheets transplanted, BM-MSC; BM-MSC sheets transplanted. CELLSHIFTER size: 3 × 6 mm, Forceps width: 4 mm, Forceps wire node length: 1 mm. EGFP positive signal percentage index: negative - 0, week positive - 50, positive – 100. Adhesion score index: negative - 0, week positive - 0.5, positive – 1. MSC sheets transplanted animal, n = 9 (transplanted site, n = 18).