Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 27;8:11314. doi: 10.1038/s41598-018-29617-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Evaluation of MSC sheets endoscopic transplantation in DNBS colitis model. (a) Endoscopic images of MSC sheets transplantation in DNBS colitis model. The yellow arrow points to the transplantation site. (b) The time-course body weight change on transplanted and non-transplanted MSC sheets. (c) The evaluation of animal model clinical severity assessed by DAI scores. DAI calculated by the combined score of weight loss, stool consistency, and bleeding, as detailed in Table 1. (d) The changes in ulcer size before and after D0 between D3 (±SEM n = 12, each). **P < 0.01, *P < 0.05. (e) Endoscopic score changes of D0 and D3. D0; transplantation day, D3; 3 days after transplantation (±SEM n = 12, each). **P < 0.01. Sham: transplantation of CELLSHIFTER without MSC sheets, AD-MSC; AD-MSC sheets transplanted, BM-MSC; BM-MSC sheets transplanted. (f) Histological analysis of colon tissue 1 day after MSC sheets. (middle; AD-MSC, lower; BM-MSC) attachment group. (g) Histological analysis of colon tissue 3 day after MSC sheets. (middle; AD-MSC, lower; BM-MSC) attachment group. Sham; transplanted CELLSHIFTER without MSC sheets, AD-MSC; AD-MSC sheets transplanted, BM-MSC; BM-MSC sheets transplanted. The red fluorescent signal is an EGFP signal in immunofluorescence, Dark brown stain was EGFP signal in DAB stain. GFP/E-Cad/DAPI; immunofluorescence stain, Brown GFP; immunohistochemistry, HE; Hematoxylin and eosin stain. Bars represent 200 μm.