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. 2018 Jul 27;8:11312. doi: 10.1038/s41598-018-29631-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Removal of subretinal debris in RCS rats preserves photoreceptors. (A) OCT and fundus image before surgery. (B) After the surgery, debris-free area in OCT image is outlined with a white arrow. Retina became more transparent on fundus photography (within the yellow dotted line). (C) Serial OCT scans demonstrate better preservation of photoreceptors in treated eyes, as compared to control eyes. Photoreceptor outer segments reappear a few days after debridement (yellow arrows). (D) ONL is significantly thicker in the treated area than in the corresponding controls. In treated eyes, the ONL thickness at P180 is equivalent to that of P60 in controls (n = 10 control eyes and 10 treated eyes in 10 animals, error bars - s.e.m., *p < 0.01, two-sided paired t-test, p-values respectively 0.36, 2.5E-05, 8.2E-07, 2.2E-05, 0.00023, 0.0014, 5.8E-05).