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. 2018 Jul 27;8:11312. doi: 10.1038/s41598-018-29631-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histology of surgically treated and control eyes. (A) Upper row: histology of the 38, 120, and 180-day old RCS rats in the surgically-treated area. Middle row: untreated retina in the same eye. Bottom row: and contralateral control eye. Treated retina exhibited much thicker ONL than both controls. Note that after subretinal lavage, subretinal debris was removed (P38, arrow head) and outer-segments reappear (P120, arrow). (B) Number of the photoreceptor nuclei per 100 µm in the surgically treated retina, untreated retina, and control eye (n = 3 control eyes and 3 treated eyes in 3 animals).