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. 2018 Jul 27;8:11312. doi: 10.1038/s41598-018-29631-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histology of the laser-treated and control eyes. (A) The representative histology of 52, 110, and 180-day old RCS rat retinas from laser-treated area (upper row), untreated retina in the same eye (middle row), and contralateral control eye (bottom row). Much thicker ONL is evident in the treated area than in both controls. (B) Number of the photoreceptor nuclei per 100 µm in the laser-treated retina, untreated retina, and control eyes (n = 8 control eyes and 8 treated eyes in 8 animals, error bars - s.e.m; *p < 0.001, two-sided paired t-test).