Table 2.
Correlations between α-diversity, health-related variables and CAG-abundance in the complete dataset (n = 441). Spearman’s rho and FDR-adjusted p-values (in parenthesis) are shown. Abbreviations as in Table 1.
| CAG | |||||
|---|---|---|---|---|---|
| Prevotella | Lachnospiraceae | Pathogen | Akkermansia-Bacteroidales | Ruminococcaceae | |
| Anthropometric measures | |||||
| BMI (kg/m2) | 0.07 (0.31) | 0.12 (0.05) | 0.16 (0.002) | −0.16 (0.002) | −0.13 (0.03) |
| Body fat (%) | −0.02 (0.77) | 0.07 (0.31) | 0.00 (0.98) | −0.05 (0.50) | 0.01 (0.90) |
| Waist circumference (cm) | 0.10 (0.08) | 0.09 (0.14) | 0.16 (0.002) | −0.21 (<0.0001) | −0.12 (0.04) |
| Lipid profile | |||||
| Total cholesterol (mg/dL) | 0.01 (0.95) | 0.07 (0.28) | −0.03 (0.67) | 0.01 (0.93) | 0.00 (0.97) |
| HDL (mg/dL) | −0.12 (0.04) | 0.02 (0.74) | −0.10 (0.09) | 0.09 (0.15) | 0.05 (0.43) |
| LDL (mg/dL) | 0.04 (0.58) | 0.06 (0.37) | −0.06 (0.34) | 0.00 (0.97) | 0.02 (0.74) |
| Triglycerides (mg/dL) | 0.10 (0.10) | 0.07 (0.25) | 0.06 (0.37) | −0.07 (0.28) | −0.10 (0.09) |
| Adiponectin (µg/ml) | −0.15 (0.004) | 0.02 (0.79) | −0.13 (0.02) | 0.08 (0.20) | 0.10 (0.11) |
| Glucose metabolism | |||||
| Glucose (mmol/L) | 0.12 (0.04) | 0.05 (0.47) | 0.10 (0.08) | −0.11 (0.06) | −0.05 (0.48) |
| Insulin (µU/ml) | 0.03 (0.71) | 0.00 (0.95) | 0.09 (0.16) | −0.08 (0.24) | −0.07 (0.25) |
| Glycated hemoglobin (%) | 0.06 (0.37) | −0.08 (0.21) | −0.01 (0.88) | −0.02 (0.78) | 0.07 (0.31) |
| HOMA-IR | 0.08 (0.19) | −0.03 (0.67) | 0.03 (0.65) | −0.05 (0.47) | −0.05 (0.42) |
| Blood pressure (BP) | |||||
| Systolic BP (mm Hg) | 0.13 (0.02) | 0.12 (0.04) | 0.17 (0.002) | −0.18 (0.0008) | −0.22 (<0.0001) |
| Diastolic BP (mm Hg) | 0.09 (0.12) | 0.11 (0.06) | 0.17 (0.001) | −0.16 (0.003) | −0.21 (<0.0001) |
| Inflammation | |||||
| hs-CRP (mg/L) | 0.05 (0.47) | 0.09 (0.16) | 0.11 (0.05) | −0.08 (0.24) | −0.09 (0.12) |
| Macronutrient consumption | |||||
| Total protein (%) | −0.08 (0.21) | 0.00 (0.95) | 0.06 (0.37) | 0.10 (0.11) | 0.00 (0.97) |
| Animal protein (%) | −0.01 (0.93) | −0.07 (0.32) | 0.09 (0.14) | 0.03 (0.71) | −0.09 (0.13) |
| Total fat (%) | 0.09 (0.16) | −0.03 (0.65) | 0.03 (0.67) | 0.01 (0.85) | −0.04 (0.62) |
| Saturated fat (%) | 0.12 (0.05) | 0.01 (0.88) | 0.02 (0.84) | 0.00 (0.95) | −0.06 (0.35) |
| Monounsaturated fat (%) | 0.09 (0.18) | −0.05 (0.43) | −0.02 (0.80) | 0.03 (0.70) | −0.03 (0.72) |
| Polyunsaturated fat (%) | 0.07 (0.26) | −0.05 (0.51) | −0.01 (0.87) | 0.01 (0.87) | −0.04 (0.64) |
| Carbohydrates (%) | −0.05 (0.42) | 0.03 (0.65) | −0.05 (0.44) | −0.06 (0.35) | 0.01 (0.88) |
| Dietary fiber (g) | 0.06 (0.40) | 0.04 (0.64) | −0.07 (0.25) | −0.04 (0.62) | 0.04 (0.62) |
| Alpha diversity | |||||
| Species richness | 0.02 (0.83) | −0.13 (0.03) | −0.29 (<0.0001) | 0.13 (0.02) | 0.71 (<0.0001) |
| Shannon index | 0.11 (0.08) | 0.18 (0.0008) | −0.23 (<0.0001) | −0.01 (0.88) | 0.61 (<0.0001) |
| Pielou’s J | 0.12 (0.04) | 0.27 (<0.0001) | −0.18 (0.0006) | −0.05 (0.49) | 0.52 (<0.0001) |