Fig. 1.

Meiotic drive in C57Bl/6×SJL F₁ hybrid mice. a Schematic showing the location of the probes used (major satellite TALE, Maj.Sat.-mClover, green; minor satellite TALE, Min.Sat.-mRuby, blue; Spc24-mCherry, magenta; chromatin, H2B-mCherry, dark grey). b Z-projection of all bivalents within an oocyte, showing major satellite repeats (Maj.Sat.-mClover, green) and chromatin (H2B-mCherry, grey). Insets show both driving bivalents (identified by * and **) and, readily distinguished by their unique Maj.Sat. staining. c Intensity ratios for major satellite (green), minor satellite (blue) and Spc24 (magenta) signals on driving bivalent with extreme major satellite asymmetry. For each ratio, the bivalent half containing the larger major satellite repeat was the denominator. Representative images of these three regions are shown, oriented with the smaller major satellite repeat above the dotted line. The schematic displays the relative sizes of the major and minor satellites and Spc24 for each half of the bivalent, and the associated percentage retention in the egg. In parenthesis, number of bivalents examined, combined from three independent experiments. Error bars are 95% confidence intervals. b, c Scale bar is 2 µm