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. 2018 Jul 27;9:2952. doi: 10.1038/s41467-018-05338-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Meiotic drive requires aurora kinase activity. a The driving bivalent was denoted as having the large Maj.Sat. signal facing towards either the oocyte cortex (Maj.Sat. Cortex) or centre (Maj.Sat. Centre). b Initial and final bivalent orientation, measured at the time of first bi-orientation (initial), and the frame immediately before anaphase (final) in oocytes treated with or without the DN-aurora kinase C construct (P values from Fisher’s exact test). Numbers of bivalents examined are given, with two independent experiments using the construct and five without. c, d Representative images of an oocyte expressing H2B-mCherry (grey) and Maj.Sat.-mClover (green), displaying the driving bivalent with persistent ‘Maj.Sat. Cortex’ orientation (c), and rotation from ‘Maj.Sat. Centre’ to ‘Maj.Sat. Cortex’ (d). The driving bivalent is indicated with an asterisk and enlarged in the lower image (c, d). Scale bars represent 2 µm. Times are h:mm after NEBD. e, f Time course of driving bivalent orientation (Maj.Sat. Cortex, red; Maj.Sat. Centre, blue; undefined, grey) from NEBD to anaphase or 10 h after NEBD as shown in ‘c’ and ‘d’ in the absence (e) or presence (f) of DN-aurora kinase C. Oocytes are sorted by the initial orientation of the driving bivalent (initial Maj.Sat. Cortex, top; initial Maj.Sat. Centre, bottom)