Figure 2.

Circulating apelin receptor early endogenous ligand (ELABELA) is not decreased in preeclampsia. A and B: ELABELA levels were not altered significantly between groups: U-test (A) with the receiver operator curve (B) producing an area under the curve (AUC) of 0.55. C and D: In contrast, circulating soluble fms-like tyrosine kinase-1 (sFLT1) levels were significantly higher when measured in the preeclamptic cohort (C), with a receiver operator area under the curve of 1.0 (D). Data are shown with boxes representing the median ± interquartile range and bars representing the 5th to 95th percentile. Plasma levels of proteins detected by human enzyme immunoassay in preeclamptic women (n = 32) and controls (n = 32) matched for gestation at blood sampling. ^∗P < 0.0001 versus control.