Table 1.
ELABELA/APLN/APLNR/FLT1 Placental Samples: Clinical Characteristics
| Patient characteristic | Pregnancy controls (n = 82) | Preeclampsia (n = 82) | P value |
|---|---|---|---|
| Maternal age at delivery (years), median (IQR) | 30.2 (25.6–32.7) | 29.6 (25.9–33.4) | 0.545 |
| Gestation at delivery (weeks), median (IQR) | 40.4 (39.4–40.9) | 40.1 (38.7–40.8) | 0.01 |
| BMI (kg/m2), median (IQR) | 26.3 (23.7–30.0) | 26.7 (23.6–31.1) | 0.002 |
| Highest SBP before labor (mmHg), median (IQR) | 120 (116–130) | 140 (129.8–150) | <0.0001 |
| Highest DBP before labor (mmHg), median (IQR) | 75.5 (70–80) | 90.0 (80–98) | <0.0001 |
| Birthweight (g), median (IQR) | 3550 (3380–3759) | 3530 (3083–3810) | 0.062 |
| Smoking, n | 10 | 11 | 1 |
All women were nulliparous. Cases and controls were perfectly matched for fetal sex, labor status, and caesarean section. The Wilcoxon rank-sum test was used to compare medians. The McNemar test was used to compare paired nominal data (discordant smoking status, 3 pairs out of 82).
APLN, apelin; APLNR, apelin receptor; BMI, body mass index; DBP, diastolic blood pressure; ELABELA, apelin receptor early endogenous ligand; IQR, interquartile range; SBP, systolic blood pressure; FLT1, Fms-like tyrosine kinase-1.