Table 2.
Change of thyroid function and associating parameters during the study period in thyrotoxicosis and control groups.
| Thyroid function test results and associated parameters | Visit 1 | Visit 2 | Visit 3 | Visit 4 | Visit 5 | P valuea | ||||||
| Thyrotoxicosis group, n | 28 | 28 | 28 | 23 | 5 | — | ||||||
|
|
Free thyroxine (ng/dL), mean (SD) | 3.08 (1.09) | 2.02 (0.61) | 1.66 (0.64) | 1.60 (0.59) | 1.96 (0.39) | <.001b | |||||
|
|
Thyroid stimulating hormone (mIU/L), median (IQRc) | 0.01 (0.00) | 0.01 (0.00) | 0.01 (0.13) | 0.01 (0.10) | 0.01 (0.10) | .114d | |||||
|
|
Hyperthyroid Symptom Scale, median (IQR) | 12.5 (10.0) | 5.5 (7.8) | 4.0 (8.8) | 3.5 (4.5) | 7.0 (4.5) | <.001d | |||||
|
|
On-site resting heart rate (bpme), mean (SD) | 101.6 (14.5) | 94.4 (15.4) | 90.1 (17.6) | 85.5 (12.0) | 83.5 (4.0) | .015b | |||||
|
|
WD-rHR-ownf (bpm), mean (SD) | 88.0 (11.5) | 82.9 (10.9) | 75.9 (8.8) | 76.2 (8.0) | 72.7 (7.2) | <.001b | |||||
|
|
WD-rHR-Fitbitg (bpm), mean (SD) | 82.2 (12.5) | 76.8 (9.5) | 70.8 (8.4) | 71.4 (7.8) | 74.7 (9.8) | <.001b | |||||
| Control group, n | 10 | 10 | 10 | — | — | — | ||||||
|
|
Free thyroxine (ng/dL), mean (SD) | 1.36 (0.12) | 1.37 (0.13) | 1.35 (0.10) | — | — | .285b | |||||
|
|
Thyroid stimulating hormone (mIU/L), median (IQR) | 1.33 (1.19) | 1.62 (2.21) | 2.06 (1.21) | — | — | .236d | |||||
|
|
Hyperthyroid Symptom Scale, median (IQR) | 0.5 (2.8) | 0.0 (2.0) | 0.0 (2.0) | — | — | .504d | |||||
|
|
On-site resting heart rate (bpm), mean (SD) | 81.9 (14.8) | 81.0 (13.2) | 76.4 (11.2) | — | — | .250b | |||||
|
|
WD-rHR-own (bpm), mean (SD) | 65.8 (8.0) | 63.2 (7.4) | 64.5 (9.2) | — | — | .374b | |||||
|
|
WD-rHR-Fitbit (bpm), mean (SD) | 66.5 (8.2) | 64.3 (7.3) | 64.3 (7.7) | — | — | .101b | |||||
aVisit 1 to 3 were compared both in thyrotoxicosis and control groups.
bDerived from ANOVA with repeated measures with a Greenhouse-Geisser correction.
cIQR: interquartile range.
dDerived from Friedman test.
ebpm: beats per minute.
fWD-rHR-own: the resting heart rate from wearable device derived by own algorithm.
gWD-rHR-Fitbit: the resting heart rate from wearable device derived by Fitbit algorithm.