Fig. 5.

Druggable gene and protein expression outliers. Outlier expression analysis for mRNA (a) and protein and phosphoproteins (b) in TCGA tumors. Intensity of shading corresponds to percentage of tumor samples in a specific cancer type (x-axis) that has outlier expression in a specific gene (y-axis). The scale is limited to 30%; any percentage higher than this will be displayed as the same color. The bar graphs show how many tumors have outlier expression in each specific gene. Blue refers to potential druggable cancer-type-specific tumors and maroon refers to potential druggable “cancer-type-non-specific” tumors. In b, protein and phosphoproteins are represented, with phosphoproteins distinguished by a “:” followed by the phosphorylation site