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. 2018 Jul 27;19:555. doi: 10.1186/s12864-018-4947-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Number of identified shortest paths. Paths (of length ≤ 5) connecting (a) HPI-network, (b) the M. tuberculosis H37Rv (Mtb) hypoxic-GRN, and (c) the hypoxic-metabolism network of Mtb during its sustenance inside the host cell. The (shortest) paths were traced through a Mtb PPI network (derived from STRING database), and paths wherein at least 50% of the constituent nodes (genes/proteins) were observed to be perturbed during hypoxia were selected