Table 4.

Estimates for the absolute risk reduction expected in the ABC PICU trial

	Analytic cohort study: Gauvin et al. [1]	Descriptive cohort study: Karam et al. [2]
Storage time cutoff for “fresh” RBC unit	7 days	7 days
PICU expected length of stay	> 24 h	> 48 h
Hemodynamically unstable patients	No	Yes
NPMODS in transfused patients	15%	39.2%
Odds ratio for development of NPMODS in older versus fresher (confidence interval)	1.39 (0.42–4.61)	1.54 (0.80–2.96)
Estimated risk in experimental group 1/OR = (p1/(1 − p1))/(p0/(1 − p0))	11%	22%

MODS multiple organ dysfunction syndrome, NPMODS new or progressive multiple organ dysfunction syndrome, OR odds ratio, PICU pediatric intensive care unit, RBC red blood cell, RCT randomized controlled trial