Table 4.
Factors associated with HBeAg loss in HBeAg-positive patients
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| Hazard Ratio (95% CI) | P Value | Hazard Ratio (95% CI) | P Value | |
| Age: ≥ 40 vs < 40 years old | 0.693 (0.408–1.179) | 0.1761 | ||
| Sex: Man vs Woman | 1.103 (0.609–1.996) | 0.7466 | ||
| Genotype: C vs B | 1.118 (0.661–1.892) | 0.6774 | ||
| Cirrhosis: Yes vs No | 1.150 (0.617–2.144) | 0.6591 | ||
| HBsAg: 2900–12,000 vs < 2900 or > 12,000 IU/mL |
2.696 (1.555–4.673) | 0.0004 | 2.108 (1.133–3.924) | 0.0186 |
| HBV DNA: ≥ 8.3 vs < 8.3 log10 IU/mL |
0.938 (0.534–1.646) | 0.8223 | ||
| ALT: ≥ 5 × vs < 5 × ULN | 2.452 (1.433–4.195) | 0.0011 | 2.055 (1.145–3.690) | 0.0158 |
| Total bilirubin: ≥ 1.2 vs < 1.2 mg/dL |
1.622 (0.959–2.744) | 0.0713 | ||
| PT: seconds prolonged | 1.130 (0.995–1.282) | 0.0592 | 1.140 (0.981–1.325) | 0.0865 |
| Platelet: ≥ 150 vs < 150 × 103/μL | 1.551 (0.887–2.710) | 0.1234 | ||
| AFP: ≥ 20 vs < 20 ng/mL | 3.178 (1.732–5.829) | 0.0002 | 2.583 (1.258–5.303) | 0.0097 |
| CLEC18: pg/mL | 1.000 (0.999–1.000) | 0.2708 | ||
| CLEC18: 320–2000 vs < 320 or > 2000 pg/mL |
2.842 (1.637–4.933) | 0.0002 | 2.077 (1.066–4.046) | 0.0318 |