Table 1.

Overview of patient cohort studies investigating viral and disease factors linked with bnAb development

Reference	Number of subjectsa	Investigated viral and disease factors	Association with breadth	Additional information on investigated parameter
Doria-Rose et al. [11]	103	Viral load	Positive	Contemporaneous
		Infection duration	None
		Transmission mode	None
		CD4+ T cell levels	None	Contemporaneous
		History of ART use	None
Euler et al. [6]	82	Viral load	Positive	Set point
		CD4+ T cell levels	Negative	Set point
		Disease progression	None
Gray et al. [33]	40	Viral load	Positive	Set point
		CD4+ T cell levels	Negative	6 months post-infection
		CD4+ T cell decline	Positive	Difference between levels pre-infection and at 6 months
Landais et al. [14]	439	Viral load	Positive	Set point
		Infecting subtype	Positive	Subtype C infection
		Infection duration	Positive
		Transmission mode	None
		CD4+ T cell levels	Negative	All tested time points beyond 6 months post-infection
Mikkell et al. [32]	38	Viral load	Positive	Contemporaneous
Piantadosi et al. [48]	70	Viral load	Positive	Set point
		Viral diversity	Positive	Env
		CD4+ T cell levels	None	Contemporaneous
		Disease progression	None
Rusert et al. [12]	4484	Viral load	Positive	Contemporaneous
		Viral diversity	Positive	Pol
		Infecting subtype	None
		Infection duration	Positive
		Transmission mode	Weakly positive	Modestly higher bnAb activity in IDUs
		CD4+ T cell levels	Weakly positive	Contemporaneous; modest association with cross-neutralization activity
Sather et al. [49]	39	Viral load	Positive	Average of all tested time points
		Infection duration	Positive
		CD4+ T cell levels	None	Average of all tested time points
van Gils et al. [50]	35	Viral load	Positive	Set point
		CD4+ T cell levels	Negative	Set point

^aIndicates total number of subjects included. Specific analyses may have been carried out on subsets of these numbers