Table 8. Function, related diseases and description of the most significant (upregulated).

Genes	Full name	Function	Related diseases and description
PEG3	Paternally Expressed Gene 3	• protein coding gene.	• Hypermethylation of PEG3 is linked to epigenetics mechanism and HPV infection in cervical intraepithelial neoplasia (CIN) and Invasive Cervical Cancer. (Nye et al., 2013) • Cell proliferation and p53-mediated apoptosis. (Yamaguchi et al., 2002) • Involvement in the glioma and ovarian cancers (Jiang et al., 2010)
SPON1	F-spondin 1	• extracellular matrix organization regulation, interaction between cells and axon guidance (Burstyn-Cohen et al., 1999)	• Showed extreme expression activities in the identification of colorectal biomarkers (Pagnotta et al., 2013) • Down regulation activity in the cervical cell carcinoma (Zhai et al., 2010)
BTD	bitonidase	• gene expression, proliferation and differentiation of cells, gene signaling (Faith & Abraham, 2013)	• gene expression signature that marks pelvic lymph node metastasis (PLNM) in cervical carcinoma (Huang et al., 2011) • Involvement in thyroid and lung cancers (So et al., 2012; Scheerger & Zempleni, 2003) • Potential serological marker in breast cancer plasma (Kang et al., 2010)
RPLP2	Ribosomal Protein Lateral Stalk Subunit P2	• encodes a 60s subunit ribosomal protein.	• prognostic marker for gastric cancer (Zhang et al., 2011) • involved in the carcinogenesis and progression of various cancers (Sharp et al., 1990) • associated with other ribosomal protein genes with colorectal carcinomas (CRC) (Mao-De & Jing, 2007)