Table 2. In vitro activities of antifungals and tigecycline combinations against planktonic cells.
The FICI was determined as the combined concentration of antimicrobials divided by the single concentration. The combination value was derived from the highest dilution of the antimicrobial combination that permitted no visible growth. FICI of ≤0.5 was considered synergistic, of >0.5–4 was considered additive indifferent, and of >4.0 was considered antagonistic.
| FIC index | |||||
|---|---|---|---|---|---|
| AMB | FLC | ITC | ANI | CAS | |
| C.albicans 1 | 0.375 | 5 | 1.5 | 2.5 | 5 |
| C.albicans 2 | 0.375 | 2 | 1 | 0.56 | 1.5 |
| C.albicans 3 | 0.325 | 2 | 2.5 | 2 | 3 |
| C.albicans 4 | 0.56 | 1 | 5 | 1 | 1.5 |
| C.albicans SC5314 | 0.375 | 2 | 5 | 1 | 0.18 |
Notes.
- AMB
- Amphotericin B
- FLC
- Fluconazole
- ITC
- Itraconazole
- ANI
- Anidulafungin
- CAS
- Caspofungin