Table 3. In vitro activities of antifungals and tigecycline combinations against mature biofilms.
Interactions on mature biofilm in SMIC | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
AMB | FLC | ITC | ANI | CAS | ||||||
D/I | µg ml−1 | D/I | µg ml−1 | D/I | µg ml−1 | D/I | µg ml−1 | D/I | µg ml−1 | |
C.albicans 1 | 2× | 0.5 | 2× | 16 | (+)2× | 1 | 1× | 64 | 2× | 0.25 |
C.albicans 2 | 2× | 2 | (+)8× | 256 | (+)8× | 16 | (+)4× | 1 | 4× | 0.06 |
C.albicans 3 | 2× | 8 | 1× | >1024 | (+)2× | 4 | 1× | 32 | 8× | 0.06 |
C.albicans 4 | 1× | 8 | 1× | 1024 | 1× | 8 | 2× | 0.125 | 1× | 0.125 |
C.albicans SC5314 | 2× | 4 | 1× | 8 | 1× | 8 | 1× | 2 | 1× | 0.25 |
Notes.
D/I: Decrease or Increase 1×, no significant decrease; 2–8×, 2–8 fold decrease in SMIC. (+)2–8 fold increase in SMIC.
- AMB
- Amphotericin B
- FLC
- Fluconazole
- ITC
- Itraconazole
- ANI
- Anidulafungin
- CAS
- Caspofungin