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. Author manuscript; available in PMC: 2018 Jul 28.
Published in final edited form as: Transplantation. 2011 Oct 15;92(7):759–766. doi: 10.1097/TP.0b013e31822c6e89

FIGURE 2.

FIGURE 2.

Innate inflammatory infiltrates are induced in murine cytomegalovirus (MCMV)-infected allografts and reduced with ganciclovir (GCV) treatment. (A) Cellular infiltrates from allografts of uninfected (Mock, open squares), CMV-infected (CMV, closed squares), and CMV infected, GCV-treated (GCV, hatched squares) animals were stained for CD45+/CD11b+ cells, evaluated by flow cytometry, and depicted as cells per organ. CD11b+ infiltrates were greater in the CMV grafts compared with Mock grafts (P<0.01) and were reduced in GCV grafts compared with CMV grafts (P<0.01). CD11b+ infiltrates were greater in the GCV grafts compared with Mock (P<0.05). (B) Allo-grafts were analyzed for CD11b+/CD11c+, CD11b+/Gr-1+, CD45+/CD204+, and CD3-/CD49b+ cells by flow cytometry (cells per organ). CMV grafts had greater infiltrates of all innate subsets compared with Mock grafts (P<0.01 for all except CD49b+, P<0.02). GCV grafts had lower numbers of all innate subsets compared with CMV grafts (P<0.05 for all except CD204+, P<0.02). GCV grafts contained greater numbers of CD11c+ and Gr-1+ cells (P<0.05) as well as CD204+ and CD49b+ cells (P<0.01) compared with Mock grafts.