Table 1.
Sleep and wake characteristics among age groups within BiP genotypes during lights off and lights on
| Characteristic | BiP Wildtype | BiP Heterozygous | ||||||
|---|---|---|---|---|---|---|---|---|
| Mean ± SD | ANOVA p† | Mean ± SD | ANOVA p† | |||||
| 2–3 Months (N=7) |
12 Months (N=13) |
18 Months (N=8) |
2–3 Months (N=8) |
12 Months (N=9) |
18 Months (N=6) |
|||
| Lights Off | ||||||||
| Wake | ||||||||
| Bout Duration‡ | 5.62 ± 2.14 | 3.88 ± 2.47 | 3.08 ± 1.3 | 0.0797 | 7.84 ± 4.36 | 4.50 ± 1.75 | 2.77 ± 0.65 | 0.0092 |
| Bout Number | 94.6 ± 37.2 | 138.9 ± 60.6 | 169.1 ± 70.4 | 0.0680 | 77.8 ± 26.9 | 125.8 ± 60.7 | 179.7 ± 37.7 | 0.0020 |
| Total Minutes | 469.9 ± 50.6 | 426.2 ± 79.7 | 456.0 ± 74.6 | 0.4018 | 517.3 ± 61.9 | 482.6 ± 74.1 | 477.8 ± 33.4 | 0.4117 |
| NREM | ||||||||
| Bout Duration‡ | 2.35 ± 0.69 | 2.12 ± 0.79 | 1.55 ± 0.67 | 0.1040 | 2.41 ± 0.53 | 1.93 ± 0.80 | 1.15 ± 0.26 | 0.0039 |
| Bout Number | 103.0 ± 36.1 | 142.2 ± 62.8 | 173.0 ± 72.2 | 0.1025 | 78.1 ± 26.7 | 129.6 ± 67.1 | 180.8 ± 37.0 | 0.0034 |
| Total Minutes | 225.5 ± 50.5 | 267.4 ± 78.9 | 233.5 ± 67.9 | 0.3710 | 181.7 ± 58.7 | 222.7 ± 67.5 | 201.9 ± 35.8 | 0.3636 |
| REM | ||||||||
| Bout Duration‡ | 1.08 ± 0.34 | 1.08 ± 0.19 | 0.91 ± 0.27 | 0.2974 | 1.11 ± 0.231 | 0.74 ± 0.36 | 0.99 ± 0.320 | 0.0417 |
| Bout Number | 26.9 ± 16.7 | 24.5 ± 7.1 | 32.5 ± 15.4 | 0.3804 | 19.5 ± 8.7 | 17.9 ± 11.5 | 42.0 ± 11.9 | 0.0007 |
| Total Minutes | 24.5 ± 7.0 | 26.3 ± 8.5 | 30.6 ± 13.8 | 0.4824 | 21.0 ± 9.7 | 14.7 ± 11.0 | 40.4 ± 7.9 | 0.0003 |
| Lights On | ||||||||
| Wake | ||||||||
| Bout Duration‡ | 1.63 ± 0.58 | 1.58 ± 0.56 | 1.16 ± 0.41 | 0.1574 | 1.97 ± 0.65 | 1.57 ± 0.46 | 1.14 ± 0.16 | 0.0180 |
| Bout Number | 163.6 ± 65.1 | 178.9 ± 63.0 | 288.8 ± 173.4 | 0.0497 | 144.1 ± 41.3 | 185.9 ± 67.2 | 285.3 ± 38.6 | 0.0003 |
| Total Minutes | 239.8 ± 45.7 | 256.7 ± 51.7 | 281.4 ± 54.1 | 0.2955 | 269.3 ± 61.9 | 271.3 ± 63.9 | 320.1 ± 14.3 | 0.1887 |
| NREM | ||||||||
| Bout Duration‡ | 2.51 ± 0.9 | 2.32 ± 0.87 | 1.54 ± 0.71 | 0.0672 | 2.76 ± 0.76 | 2.25 ± 0.77 | 1.10 ± 0.17 | 0.0006 |
| Bout Number | 182.9 ± 56.5 | 193.5 ± 60.0 | 302.9 ± 189.8 | 0.0720 | 151.6 ± 41.6 | 200.2 ± 80.2 | 294.3 ± 39.8 | 0.0010 |
| Total Minutes | 417.1 ± 48.2 | 409.9 ± 55.7 | 376.4 ± 71.6 | 0.3497 | 394.0 ± 56.3 | 410.8 ± 65.8 | 318.7 ± 22.6 | 0.0125 |
| REM | ||||||||
| Bout Duration‡ | 1.12 ± 0.32 | 1.03 ± 0.31 | 0.89 ± 0.33 | 0.3954 | 1.20 ± 0.17 | 0.85 ± 0.39 | 0.86 ± 0.18 | 0.0349 |
| Bout Number | 62.9 ± 31.3 | 56.2 ± 18.7 | 72.6 ± 33.0 | 0.4041 | 48.4 ± 18.1 | 43.1 ± 22.8 | 97.5 ± 24.1 | 0.0003 |
| Total Minutes | 63.2 ± 15.9 | 53.5 ± 11.4 | 62.2 ± 27.5 | 0.4278 | 56.7 ± 18.3 | 37.8 ± 20.2 | 81.2 ± 12.5 | 0.0007 |
†
p-value testing the global null hypothesis of no differences in sleep and wake characteriscs across age groups;
‡
Average bout duration in minutes; Nominally significant ANOVA p-values (p<0.05) shown in bold.