Table 2.
Sleep and wake characteristics between BiP genotypes within age groups during lights off and lights on
| Characteristic | 2–3 Months | 12 Months | 18 Months | ||||||
|---|---|---|---|---|---|---|---|---|---|
| BiP-WT (N=7) |
BiP-HET (N=8) |
p† | BiP-WT (N=13) |
BiP-HET (N=9) |
p† | BiP-WT (N=8) |
BiP-HET (N=6) |
p† | |
| Lights Off | |||||||||
| Wake | |||||||||
| Bout Duration‡ | 5.62 ± 2.14 | 7.84 ± 4.36 | 0.2451 | 3.88 ± 2.47 | 4.50 ± 1.75 | 0.5235 | 3.08 ± 1.3 | 2.77 ± 0.65 | 0.6053 |
| Bout Number | 94.6 ± 37.2 | 77.8 ± 26.9 | 0.3297 | 138.9 ± 60.6 | 125.8 ± 60.7 | 0.6246 | 169.1 ± 70.4 | 179.7 ± 37.7 | 0.7467 |
| Total Minutes | 469.9 ± 50.6 | 517.3 ± 61.9 | 0.1322 | 426.2 ± 79.7 | 482.6 ± 74.1 | 0.1089 | 456.0 ± 74.6 | 477.8 ± 33.4 | 0.5201 |
| NREM | |||||||||
| Bout Duration‡ | 2.35 ± 0.69 | 2.41 ± 0.53 | 0.8673 | 2.12 ± 0.79 | 1.93 ± 0.80 | 0.5887 | 1.55 ± 0.67 | 1.15 ± 0.26 | 0.1883 |
| Bout Number | 103.0 ± 36.1 | 78.1 ± 26.7 | 0.1497 | 142.2 ± 62.8 | 129.6 ± 67.1 | 0.6574 | 173.0 ± 72.2 | 180.8 ± 37.0 | 0.8134 |
| Total Minutes | 225.5 ± 50.5 | 181.7 ± 58.7 | 0.1477 | 267.4 ± 78.9 | 222.7 ± 67.5 | 0.1815 | 233.5 ± 67.9 | 201.9 ± 35.8 | 0.3228 |
| REM | |||||||||
| Bout Duration‡ | 1.08 ± 0.34 | 1.11 ± 0.23 | 0.8463 | 1.08 ± 0.19 | 0.74 ± 0.36 | 0.0248 | 0.91 ± 0.27 | 0.99 ± 0.320 | 0.5334 |
| Bout Number | 26.9 ± 16.7 | 19.5 ± 8.7 | 0.2946 | 24.5 ± 7.1 | 17.9 ± 11.5 | 0.1081 | 32.5 ± 15.4 | 42.0 ± 11.9 | 0.2349 |
| Total Minutes | 24.5 ± 7.0 | 21.0 ± 9.7 | 0.4444 | 26.3 ± 8.5 | 14.7 ± 11.0 | 0.0112 | 30.6 ± 13.8 | 40.4 ± 7.9 | 0.1470 |
| Lights On | |||||||||
| Wake | |||||||||
| Bout Duration‡ | 1.63 ± 0.58 | 1.97 ± 0.65 | 0.3043 | 1.58 ± 0.56 | 1.57 ± 0.46 | 0.9374 | 1.16 ± 0.41 | 1.14 ± 0.16 | 0.8933 |
| Bout Number | 163.6 ± 65.1 | 144.1 ± 41.3 | 0.4958 | 178.9 ± 63.0 | 185.9 ± 67.2 | 0.8044 | 288.8 ± 173.4 | 285.3 ± 38.6 | 0.9583 |
| Total Minutes | 239.8 ± 45.7 | 269.3 ± 61.9 | 0.3189 | 256.7 ± 51.7 | 271.3 ± 63.9 | 0.5584 | 281.4 ± 54.1 | 320.1 ± 14.3 | 0.0878 |
| NREM | |||||||||
| Bout Duration‡ | 2.51 ± 0.9 | 2.76 ± 0.76 | 0.5647 | 2.32 ± 0.87 | 2.25 ± 0.77 | 0.8544 | 1.54 ± 0.71 | 1.10 ± 0.17 | 0.1264 |
| Bout Number | 182.9 ± 56.5 | 151.6 ± 41.6 | 0.2402 | 193.5 ± 60.0 | 200.2 ± 80.2 | 0.8230 | 302.9 ± 189.8 | 294.3 ± 39.8 | 0.9046 |
| Total Minutes | 417.1 ± 48.2 | 394.0 ± 56.3 | 0.4126 | 409.9 ± 55.7 | 410.8 ± 65.8 | 0.9709 | 376.4 ± 71.6 | 318.7 ± 22.6 | 0.0614 |
| REM | |||||||||
| Bout Duration‡ | 1.12 ± 0.32 | 1.20 ± 0.17 | 0.5292 | 1.03 ± 0.31 | 0.85 ± 0.39 | 0.2406 | 0.89 ± 0.33 | 0.86 ± 0.18 | 0.8400 |
| Bout Number | 62.9 ± 31.3 | 48.4 ± 18.1 | 0.2842 | 56.2 ± 18.7 | 43.1 ± 22.8 | 0.1548 | 72.6 ± 33.0 | 97.5 ± 24.1 | 0.1460 |
| Total Minutes | 63.2 ± 15.9 | 56.7 ± 18.3 | 0.4852 | 53.5 ± 11.4 | 37.8 ± 20.2 | 0.0309 | 62.2 ± 27.5 | 81.2 ± 12.5 | 0.1432 |
†
p-value from T-test comparing sleep and wake characteristics between wildtype and heterozygous animals within each age group;
‡
Average bout duration in minutes; nominally significant genotype differences (p<0.05) shown in bold.