Table 4.

Spike and slab characteristics between BiP genotypes within age groups during lights off and lights on

Characteristic	2–3 Months			12 Months			18 Months
Characteristic	BiP-WT (N=7)	BiP-HET (N=8)	p^†	BiP-WT (N=13)	BiP-HET (N=9)	p^†	BiP-WT (N=8)	BiP-HET (N=6)	p^†
Lights Off
Wake to NREM
Number of bouts	93.9 ±37.2	77.1 ± 27.0	0.3323	141.5 ± 62.5	117.6 ± 44.1	0.3339	168.9 ± 70.6	178.7 ± 37.7	0.7645
Proportion short^‡	0.111 ± 0.029	0.123 ± 0.044	0.5493	0.106 ± 0.055	0.115 ± 0.055	0.7092	0.141 ± 0.086	0.203 ± 0.101	0.2394
Average duration^§	2.76 ± 0.89	2.70 ± 0.56	0.8785	2.38 ± 0.78	2.17 ± 0.72	0.5293	1.71 ± 0.69	1.32 ± 0.26	0.1723
NREM to Wake
Number of bouts	75.9 ± 39.2	58.4 ± 22.8	0.3027	120.5 ± 62.0	102.1 ± 44.3	0.4538	140.0 ± 78.4	139.0 ± 37.2	0.9776
Proportion short^‡	0.607 ± 0.188	0.664 ± 0.109	0.4816	0.618 ± 0.156	0.568 ± 0.148	0.4652	0.626 ± 0.203	0.702 ± 0.085	0.4081
Average duration^§	15.05 ± 15.19	21.32 ± 12.68	0.3992	7.31 ± 4.21	11.82 ± 6.30	0.0568	9.67 ± 7.35	8.49 ± 5.10	0.7419
REM to Wake
Number of bouts	18.3 ± 6.3	19.0 ± 9.0	0.8628	21.0 ± 8.3	15.4 ± 11.6	0.2027	28.9 ± 14.0	40.0 ± 11.3	0.1379
Proportion short^‡	0.396 ± 0.154	0.426 ± 0.169	0.7261	0.475 ± 0.222	0.535 ± 0.321	0.6087	0.470 ± 0.204	0.399 ± 0.176	0.5080
Average duration^§	15.57 ± 9.60	18.70 ± 11.19	0.5744	9.16 ± 5.833	6.21 ± 6.05	0.2641	6.23 ± 4.70	6.65 ± 3.11	0.8539
Lights On
Wake to NREM
Number of bouts	163.0 ± 65.4	143.5 ± 41.1	0.4954	166.9 ± 63.3	169.0 ± 23.95	0.9155	288.4 ± 173.5	284.7 ± 38.7	0.9548
Proportion short^‡	0.075 ± 0.026	0.071 ± 0.027	0.7451	0.088 ± 0.048	0.088 ± 0.026	0.9984	0.132 ± 0.103	0.122 ± 0.056	0.8361
Average duration^§	2.84 ± 1.01	3.01 ± 0.89	0.7340	2.85 ± 1.15	2.56 ± 0.78	0.5130	1.68 ± 0.68	1.20 ± 0.15	0.0913
NREM to Wake
Number of bouts	119.4 ± 61.5	103.0 ± 41.2	0.5489	128.3 ± 57.6	139.3 ± 28.6	0.6032	229.6 ± 189.5	196.7 ± 33.2	0.6433
Proportion short^‡	0.651 ± 0.125	0.672 ± 0.109	0.7397	0.677 ± 0.170	0.662 ± 0.162	0.8403	0.708 ± 0.163	0.737 ± 0.100	0.7088
Average duration^§	4.77 ± 3.01	5.75 ± 3.72	0.5854	5.15 ± 4.00	4.96 ± 2.69	0.8986	4.30 ± 2.50	3.16 ± 1.28	0.3322
REM to Wake
Number of bouts	43.3 ± 12.3	40.1 ± 11.0	0.6075	38.4 ± 16.6	29.6 ± 15.9	0.2261	58.4 ± 32.8	87.8 ± 21.8	0.0819
Proportion short^‡	0.651 ± 0.183	0.576 ± 0.143	0.3853	0.663 ± 0.179	0.574 ± 0.271	0.3583	0.669 ± 0.213	0.564 ± 0.128	0.3055
Average duration^§	4.41 ± 2.76	4.73 ± 3.83	0.8577	7.69 ± 6.40	4.99 ± 3.19	0.2581	3.54 ± 2.56	2.97 ± 1.02	0.6190

^†

p-value from T-test comparing sleep and wake characteristics between wildtype and heterozygous animals within each age group;

^‡

Proportion of bouts ≤40 seconds;

^§

Average long bout duration in minutes