Figure 4.
Systemic administration of PEG-GM-CSF does not increase recruitment of migrating tumor cells to tumors. (A) Blood half life of GM-CSF after a single intravenous injection of 0.05 mg/kg of PEG-GM-CSF. (B) Ex vivo bioluminescence measured in shGFP or shGM-CSF tumors in mice treated with daily injections of 20 pg PEG-GM-CSF. (C) Plasma levels of GM-CSF measured 3 and 10 days after the initiation of treatment. (D) Counts for blood cells before (Control) and at specified times following the initiation of PEG-GM-CSF treatment.