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. Author manuscript; available in PMC: 2019 Mar 28.
Published in final edited form as: Handb Exp Pharmacol. 2018;248:435–471. doi: 10.1007/164_2017_86

Figure 1. Distribution and projection of CRF, Ucn1, and CRFRs in alcohol-related regions.

Figure 1

Corticotropin-releasing factor (CRF) is more widely expressed than urocortin 1 (Ucn1); CRF type 1 receptors (CRFR1; green triangle) are expressed widely throughout the brain, while CRF type 2 receptors (CRFR2; yellow triangle) have a more restricted distribution. Corticotropin-releasing factor binding protein (CRF-BP; red diamond) is expressed in most brain regions that express CRF, Ucn1, and CRFRs. CeA, central amygdala; DRN, dorsal raphe nucleus; EWcp, centrally projecting Edinger-Westphal nucleus; LHA, lateral hypothalamus; mPFC, medial prefrontal cortex; PAG, periaqueductal grey; PVN, paraventricular nucleus of the hypothalamus