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. Author manuscript; available in PMC: 2019 Mar 28.
Published in final edited form as: Handb Exp Pharmacol. 2018;248:435–471. doi: 10.1007/164_2017_86

Table 3.

Alcohol Interactions with the Urocortin System.

Systemic/ICV CeA EWcp
Alcohol Effects on Ucn1
Low-level/Acute EtOH (Ucn1) N/A ? ↑ activation
Binge-Like Alcohol (Ucn1) N/A ? ↑ (escalation model) mRNA
Chronic Alcohol (Ucn) N/A ? ↔ content
↓ fibers projecting to lateral septum and DRN
Ucn Manipulation Effects on Alcohol Consumption
Ucn1 Effect on Low-level Alcohol Consumption ↔ (KO – DID) ? ?
Ucn1 Effect on Binge-like Alcohol Consumption ↔ (KO – DID)
↓ (KO – escalation model)		 ? ?
Ucn3 Effect on Binge-like Alcohol Consumption ↓ ? ?
Ucn3 Effects on Dependence-induced increases in Alcohol consumption ↓ ↓ ?

↑ - Increase; ↔ - No change; ↓ - Decrease. ICV, intra-ventricular; Ucn1, urocortin-1; Ucn3 – urocortin-3; CeA, central amygdala; Ewcp, centrally projecting Edinger-Westphal nucleus