Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2018 Dec 7.

Published in final edited form as: Nanoscale. 2017 Dec 7;9(47):18723–18730. doi: 10.1039/c7nr05502a

Fig. 2 — Schematics showing surface functionalization of the optimized MPI contrast agents for glioma targeting. (a) synthesis of the PMAO-PEG co-polymer, with active maleimide functional groups and (b) its assembly on the surface of the oleic acid coated nanoparticles after phase transfer to aqueous phases. (c) Thiolation of the lactoferrin molecules using Traut’s reagent and their conjugation to maleimide functionalized MPI contrast agents for in vivo brain cancer targeting experiments.

Fig. 2 — Schematics showing surface functionalization of the optimized MPI contrast agents for glioma targeting. (a) synthesis of the PMAO-PEG co-polymer, with active maleimide functional groups and (b) its assembly on the surface of the oleic acid coated nanoparticles after phase transfer to aqueous phases. (c) Thiolation of the lactoferrin molecules using Traut’s reagent and their conjugation to maleimide functionalized MPI contrast agents for in vivo brain cancer targeting experiments.