Table 4.
Most frequently changed drugs
| Interval Δ1 (baseline to 6 month follow-up) | Interval Δ2 (6-month follow-up to 9-month follow-up) | ||||||
|---|---|---|---|---|---|---|---|
| Intervention group | Control group | Intervention group | Control group | ||||
| Drug | Changes in Δ1 / total prescriptions at T0a (n / N, %) |
Drug | Changes in Δ1 / total prescriptions at T0a (n / N, %) |
Drug | Changes in Δ2 / total prescriptions at T1a (n / N, %) |
Drug | Changes in Δ2 / total prescriptions at T1a (n / N, %) |
| Simvastatin | 75 / 104 (72%) | Simvastatin | 90 / 128 (70%) | Aspirin* | 40 / 108 (37%) | Simvastatin | 72 / 121 (60%) |
| Ramipril | 70 / 67 (104%) | Aspirin* | 58 / 126 (46%) | Omeprazole | 39 / 48 (81%) | Aspirin* | 50 / 122 (41%) |
| Metformin | 63 / 61 (103%) | Metformin | 49 / 57 (86%) | Simvastatin | 38 / 107 (35%) | Metformin | 39 / 50 (78%) |
| Amlodipine | 63 / 76 (83%) | Allopurinol | 43 / 47 (91%) | Ramipril | 37 / 64 (56%) | Omeprazole | 34 / 52 (65%) |
| Metoprolol* | 59 / 69 (85%) | Amlodipine | 40 / 57 (70%) | Metformin | 34 / 60 (57%) | Torasemide | 33 / 50 (66%) |
| Bisoprolol | 58 / 62 (93%) | Pantoprazole | 39 / 33 (118%) | Torasemide | 34 / 57 (60%) | Metoprolol* | 31 / 49 (63%) |
| Omeprazole | 54 / 55 (98%) | Bisoprolol | 39 / 65 (60%) | Pantoprazole | 29 / 31 (93%) | Ramipril | 29 / 58 (50%) |
| Aspirin* | 53 / 105 (50%) | Metoprolol* | 38 / 54 (70%) | Allopurinol | 28 / 44 (64%) | Pantoprazole | 28 / 29 (96%) |
| Torasemide | 45 / 52 (87%) | Ramipril | 38 / 54 (70%) | Metoprolol* | 27 / 67 (40%) | Amlodipine | 25 / 53 (47%) |
| Allopurinol | 45 / 53 (85%) | Omeprazole | 37 / 50 (74%) | Amlodipine | 25 / 70 (36%) | Bisoprolol | 24 / 62 (39%) |
| Levothyroxine | 40 / 55 (73%) | Torasemide | 37 / 55 (67%) | Bisoprolol | 18 / 63 (29%) | Allopurinol | 23 / 44 (52%) |
| Pantoprazole | 37 / 30 (123%) | HCT | 24 / 40 (60%) | Diclofenac | 17 / 34 (50%) | Diclofenac | 22 / 12 (183%) |
| Diclofenac | 33 / 36 (92%) | Levothyroxine | 23 / 55 (42%) | Ca + D3 | 16 / 14 (114%) | HCT | 20 / 37 (54%) |
†number of changed prescriptions during the interval per number of prescriptions at the begin of the interval, percentages > 100% indicate prescriptions with more than one change during the interval under investigation. API – active pharmaceutical ingredient, Aspirin* - low dose aspirin, Ca + D3 – combination of calcium and cholecalciferol (vitamin D3), HCT – hydrochlorothiazide, Metoprolol* - metoprolol-succinate