. 2018 Jul 28;10:72. doi: 10.1186/s13195-018-0398-3

Table 2.

Overview of theoretical arguments in favor or against amyloid positron emission tomography (PET) result disclosure

		Cognitively normal		Mild cognitive impairment
Category	Arguments	Research	Clinic	Research	Clinic
Pro
Ethical	Patient autonomy	X^10,41	X^10,41	X³⁹	X⁵
Ethical	Evidence of non-maleficence	X^10,40,41	X^10,40,41
Social and legal	Cost and suffering reduction	X³⁸	X³⁸
Social and legal	Favors Alzheimer’s disease prevention	X¹⁰	X¹⁰
Psychological and behavioral	Enables early decision making	X¹⁰,^38,41	X^10,38,41	X³⁹	X⁵
	Clarifying effect of correct diagnosis	X³⁸	X³⁸	X³⁹	X⁵
	Relief related to negative amyloid PET	X^38,41	X^38,41
	Satisfies need for risk information	X⁴¹	X⁴¹
PET imaging characteristics	Amyloid PET imaging is validated			X³⁹
PET imaging characteristics	Clinical significance of amyloid PET				X⁵
Contra
Ethical	Non-maleficence	X^10,38,41	X^10,38,41	X³⁹	X⁵
	Lack of effective intervention	X10,³⁸	X10,³⁸	X³⁹
	Therapeutic misconception	X²	X²
Social and legal	Unwanted personal implications	X^38,41	X^10,38,41		X⁵
Social and legal	Social stigmatization	X^38,41	X^38,41
Psychological and behavioral	Risk of psychological distress	X^10,38,41	X^10,38,41		X⁵
	Risk of false reassurance after negative PET	X^10,41	X^10,41	X³⁹
	Misinterpretation of positive amyloid PET	X⁴¹	X⁴¹
PET imaging characteristics	Challenges related to inconclusive scans	X^10,38	X^10,38		X⁵
	Limited predictive value at level of individual	X^10,41	X^10,41
	Variation on interpretation of PET results	X¹⁰	X¹⁰