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. Author manuscript; available in PMC: 2019 Jul 17.
Published in final edited form as: Immunity. 2018 Jul 17;49(1):42–55.e6. doi: 10.1016/j.immuni.2018.06.011

Figure 3. Casp8 drives small intestinal and splenic damage.

Figure 3

(A–B) Representative (3 mice of each genotype in two independent experiments) images of hematoxylin and eosin (H&E) stained sections of small intestine (A) and spleen (B), from WT, Ripk3−/− and Casp8−/−Ripk3−/− mice at 9 hpc with PBS or LPS, as indicated (bar=100 μm). Arrows indicate damaged and sloughed cells with condensed nuclei. (C–D) Histological score of leukocyte infiltrate (inflammatory cells), condensed nuclei (apoptosis), atrophy (tissue damage) and edema (fluid accumulation) in small intestine (C), or extramedullary hematopoiesis (EMH) as well as congestion in spleen (D), in tissue sections from WT, Ripk3−/− and Casp8−/−Ripk3−/− mice at 9 hpc with PBS or LPS (n=3 to 5 for each group). N.D., not detected. Mean and range in scores are shown. Please also see Figure S3.