Table 4.
Associations of HDL-c (in mg/dl) with all-cause and cause-specific deaths in men and women with CKD.
| HDL level | Women | Men | ||||
|---|---|---|---|---|---|---|
| N/N events | HR (95% CI)* | HR (95% CI)** | N/N events | HR (95% CI)* | HR (95% CI)** | |
| All-cause death | ||||||
| ≤ 30 | 735/352 | 2.24 (1.99, 2.52) | 1.93 (1.70, 2.18) | 1728/652 | 1.70 (1.55, 1.87) | 1.55 (1.41, 1.72) |
| 31–40 | 2658/712 | 1.20 (1.09, 1.32) | 1.14 (1.03, 1.25) | 4872/1320 | 1.12 (1.04, 1.21) | 1.08 (1.00, 1.17) |
| 41–50 | 5227/1201 | ref | ref | 5142/1322 | ref | ref |
| 51–60 | 5222/1133 | 0.85 (0.79, 0.93) | 0.86 (0.80, 0.94) | 3001/814 | 0.99 (0.91, 1.08) | 0.99 (0.90, 1.08) |
| ≥ 60 | 7570/1517 | 0.76 (0.70, 0.81) | 0.75 (0.69, 0.81) | 2222/642 | 1.04 (0.95, 1.15) | 0.97 (0.88, 1.07) |
| Cardiovascular death^ | ||||||
| ≤ 30 | 731/140 | 2.27 (1.86, 2.77) | 1.80 (1.46, 2.21) | 1720/265 | 1.67 (1.44, 1.95) | 1.46 (1.24, 1.72) |
| 31–40 | 2653/252 | 1.18 (1.01, 1.38) | 1.10 (0.94, 1.29) | 4858/561 | 1.23 (1.09, 1.39) | 1.17 (1.03, 1.32) |
| 41–50 | 5209/436 | ref | ref | 5130/513 | ref | ref |
| 51–60 | 5200/411 | 0.86 (0.75, 0.98) | 0.88 (0.76, 1.00) | 2992/288 | 0.89 (0.77, 1.02) | 0.91 (0.79, 1.05) |
| ≥ 60 | 7550/577 | 0.80 (0.71, 0.91) | 0.82 (0.71, 0.93) | 2213/224 | 0.92 (0.79, 1.08) | 0.90 (0.76, 1.06) |
| Malignancy death^ | ||||||
| ≤ 30 | 731/65 | 1.89 (1.44, 2.49) | 1.81 (1.34, 2.43) | 1720/152 | 1.63 (1.34, 1.98) | 1.67 (1.35, 2.06) |
| 31–40 | 2653/149 | 1.24 (1.01, 1.52) | 1.21 (0.98, 1.50) | 4858/308 | 1.15 (0.98, 1.35) | 1.17 (0.99, 1.37) |
| 41–50 | 5209/236 | ref | ref | 5130/294 | ref | ref |
| 51–60 | 5200/233 | 0.96 (0.80, 1.15) | 0.94 (0.79, 1.14) | 2992/189 | 1.07 (0.89, 1.28) | 1.03 (0.85, 1.24) |
| ≥ 60 | 7550/285 | 0.81 (0.68, 0.96) | 0.77 (0.64, 0.94) | 2213/148 | 1.14 (0.94, 1.39) | 1.10 (0.89, 1.35) |
| Non-cardiovascular non-malignancy death^ | ||||||
| ≤ 30 | 731/140 | 1.92 (1.58, 2.33) | 1.65 (1.34, 2.03) | 1720/216 | 1.43 (1.21, 1.68) | 1.27 (1.06, 1.51) |
| 31–40 | 2653/289 | 1.18 (1.02, 1.36) | 1.09 (0.93, 1.26) | 4858/403 | 0.94 (0.83, 1.08) | 0.90 (0.79, 1.03) |
| 41–50 | 5209/487 | ref | ref | 5130/468 | ref | ref |
| 51–60 | 5200/446 | 0.85 (0.75, 0.97) | 0.89 (0.78, 1.01) | 2992/304 | 1.07 (0.92, 1.23) | 1.08 (0.94, 1.25) |
| ≥ 60 | 7550/606 | 0.78 (0.69, 0.88) | 0.82 (0.72, 0.94) | 2213/247 | 1.16 (0.99, 1.35) | 1.11 (0.94, 1.31) |
*
Model adjusted for age
**
Model adjusted for age, AA, eGFR, diabetes, hypertension, history of cardiovascular disease (coronary artery disease, congestive heart failure, cerebrovascular disease, peripheral vascular disease), malignancy, BMI group, statin use, log triglycerides and smoking