Table 1.
Baseline demographic and clinical characteristics of sickle cell patients compared to controls*
| CATEGORY | Controls | Sickle Cell (All subtypes) |
P value Sickle Cell vs Controls |
Hgb SUBTYPES
|
P value ALL Hgb subtypeS |
||
|---|---|---|---|---|---|---|---|
| SS N (%) |
SC N (%) |
SThal N (%) |
|||||
|
| |||||||
| Number of patients | 39 | 260 | 161 (62) | 68 (26) | 31 (12) | ||
|
| |||||||
| Age, years (mean ± SD) | 42.1 ± 2.0 | 37.7 ± 0.8 | .045 | 35.40 ± 1.0 | 42.5 ± 1.6 | 38.8 ± 2.3 | .005 |
|
| |||||||
| Gender male | 13 (33%) | 93 (40%) | .779 | 64 | 18 | 11 | .157 |
|
| |||||||
| Smoking status | .476 | .967 | |||||
| Never | 32 (82.1%) | 194 (74.6%) | 121 (75.2%) | 49 (72.1%) | 24 (77.4%) | ||
| Past | 1 (2.6%) | 18 (6.9%) | 10 (6.2%) | 6 (8.8%) | 2 (6.5%) | ||
| Current | 6 (15.4%) | 49 (18.8%) | 30 (18.6%) | 13 (19.1%) | 6 (19.4%) | ||
|
| |||||||
| Hydroxyurea† | <.001 | <.001 | |||||
| Never | 75 (100%) | 242 (47.2%) | 100 (31.4%) | 101 (75.9%) | 41 (66.1%) | ||
| Past | 0 (0%) | 193 (37.6%) | 61 (19.2%) | 9 (6.8%) | 8 (12.9%) | ||
| Current | 0 (0%) | 78 (15.2%) | 157 (49.4%) | 23 (17.3%) | 13 (21.0%) | ||
Hgb, hemoglobin; SC, sickle cell Hgb SC subtype; SS, sickle cell Hgb SS subtype; SThal, sickle cell Hgb SThal subtype.
*
P values less than .0125 (ie, 0.05/4) are considered significant based on Bonferroni correction and are in bold type.
†
Based on number of eyes.