Table 2.
Comparison of prevalence of systemic diseases and surgical procedures in sickle cell patients and controls (ANOVA)*
| CATEGORY | Controls N (%) |
Hgb subtypes | SC vs Control | ||
|---|---|---|---|---|---|
| SS N (%) |
SC N (%) |
SThal N (%) |
|||
| Number of patients | 39 | 161 | 68 | 31 | 260 vs 39 |
| Systemic disease | ANOVA P value | ||||
| Acute chest syndrome | 0 | 81 (50) | 19 (28) | 10 (31) | <.001 |
| Avascular necrosis of any joint | 0 | 42 (26) | 19 (28) | 13 (41) | .001 |
| Pulmonary hypertension | 0 | 37 (23) | 5 (7) | 1 (3) | <.001 |
| Stroke | 0 | 36 (22) | 4 (6) | 1 (3) | <.001 |
| Kidney disease | 0 | 35 (22) | 4 (6) | 1 (3) | <.001 |
| Hypertension | 12 (31) | 27 (16) | 22 (32) | 5 (16) | .025 |
| Liver disease | 2 (5) | 17 (11) | 1 (1) | 0 | .026 |
| Pulmonary embolism | 0 | 15 (9) | 5 (7) | 3 (9) | .262 |
| Deep venous thrombosis | 0 | 15 (9) | 3 (4) | 1 (3) | .11 |
| Seizure disorder | 1 (3) | 15 (9) | 2 (3) | 0 | .068 |
| Gallstones | 0 | 13 (8) | 2 (3) | 3 (9) | .139 |
| Diabetes | 3 (8) | 4 (2) | 5 (7) | 2 (6) | .283 |
| Surgical procedure | |||||
| Cholecystectomy | 2 (5) | 76 (47) | 16 (24) | 6 (19) | <.001 |
| Hip replacement | 0 | 19 (12) | 5 (7) | 8 (25) | .006 |
| Tonsillectomy | 0 | 16 (10) | 2 (3) | 2 (6) | .069 |
ANOVA, analysis of variance; Hgb, hemoglobin; SC, sickle cell Hgb SC subtype; SS, sickle cell Hgb SS subtype; SThal, sickle cell Hgb SThal subtype.
*
P values <.003 (ie, 0.05/16) are considered significant based on Bonferroni correction and are in bold type.