Table 3.
Baseline stage of sickle cell retinopathy and retinal findings of sickle cell eyes compared to control eyes (ANOVA)*
| CATEGORY | Control Eyes No. (%) |
All Sickle Cell Subtypes No. (%) |
Hgb subtypes
|
ANOVA P value comparing sickle cell subtypes |
||
|---|---|---|---|---|---|---|
| SS No. (%) |
SC No. (%) |
SThal No. (%) |
||||
|
| ||||||
| Number of eyes | 75 | 513 | 318 | 133 | 62 | |
|
| ||||||
| 2 (1.5%) | <.001 | |||||
| Stage 0 | 75 (100%) | 13 (2.5%) | 5 (1.6%) | 6 (9.7%) | ||
| Stage 1 | 0 (0%) | 8 (1.6%) | 5 (1.6%) | 3 (2.3%) | 0 (0.0%) | |
| Stage 2 | 0 (0%) | 379 (73.9%) | 267 (84.0%) | 64 (48.1%) | 48 (77.4%) | |
| Stage 3 | 0 (0%) | 95 (18.5%) | 34 (10.7%) | 55 (41.4%) | 6 (9.7%) | |
| Stage 4 | 0 (0%) | 17 (3.3%) | 7 (2.2%) | 9 (6.8%) | 1 (1.6%) | |
| Stage 5 | 0 (0%) | 1 (0.2%) | 0 (0.0%) | 0 (0.0%) | 1 (1.6%) | |
|
| ||||||
| Pigment | 0 (0%) | 52 (10.1 %) | 35 (11.0%) | 12 (9.0%) | 5 (8.1%) | .692 |
|
| ||||||
| Sea fan | 0 (0%) | 94 (18.3%) | 36 (11.3%) | 51 (38.3%) | 7 (11.3%) | <.001 |
|
| ||||||
| Sunburst | 0 (0%) | 159 (31.0%) | 105 (33.0%) | 33 (24.8%) | 21 (33.9%) | .199 |
|
| ||||||
| Hemorrhage | 0 (0%) | 33 (6.4%) | 14 (4.4%) | 18 (13.5%) | 1 (1.6%) | <.001 |
|
| ||||||
| Retinal finding | Mean Severity grading (SD) | ANOVA P value comparing grading among subtypes | ||||
|
| ||||||
| Tortuosity severity | N/A | 1.34 (0.07) | 1.57 (0.08) | 0.89 (0.13) | 0.63 (0.12) | <.001 (ST, SC) <SS |
|
| ||||||
| Caliber of anastomosis | N/A | 1.58 (0.06) | 1.62 (0.07) | 1.79 (0.14) | 1.04 (0.14) | <.001 ST< (SS, SC) |
ANOVA, analysis of variance; Hgb, hemoglobin; N/A, not applicable; SC, sickle cell Hgb SC subtype; SS, sickle cell Hgb SS subtype; SThal, sickle cell Hgb SThal subtype.
*
P values <.007 (ie, 0.05/7) are considered significant based on Bonferroni correction and are in bold type.