Table 4.
| A. Comparison of SDOCT subfield measurements for sickle cell eyes with control eyes (ANOVA)* | |||
|---|---|---|---|
| Subfield location | SDOCT thickness (µm) | ANOVA P VALUE | |
| Control Eyes, Mean ± SE |
Sickle cell (all subtypes) Eyes, Mean ± SE |
||
| Central | 262.8 ± 2.42 | 253.7 ± 1.05 | .002 |
| Nasal inner | 339.8 ± 2.26 | 332.1 ± 1.07 | .009 |
| Superior inner | 338.4 ± 2.23 | 331.4 ± 1.13 | .021 |
| Temporal inner | 325.0 ± 2.08 | 313.3 ± 1.20 | <.001 |
| Inferior inner | 335.9 ± 2.30 | 328.6 ± 1.11 | .017 |
| Nasal outer | 310.2 ± 2.08 | 308.3 ± 0.93 | .461 |
| Superior outer | 294.6 ± 1.88 | 292.7 ± 0.89 | .428 |
| Temporal outer | 281.7 ± 1.78 | 273.1 ± 1.28 | .012 |
| Inferior outer | 287.1 ± 1.89 | 284.5 ± 0.90 | .286 |
| B. Spectral domain optical coherence tomography subfield measurements for sickle cell eyes compared to control eyes using ANOVA* | ||||||
|---|---|---|---|---|---|---|
| ETDRS subfield |
SDOCT thickness measurements (µm) Mean ± SE |
Statistical test among sickle cell subtypes and control and post hoc comparison |
||||
| Control eyes | Sickle Cell (All subtypes) eyes |
Hgb Subtypes | ||||
| SS eyes | SC eyes | SThal eyes | ||||
| Central | 262.8 ± 2.42 | 253.7 ± 1.05 | 252.1+/− 1.33 | 259.8+/− 2.02 | 249 +/− 3.06 | <.001 SS,ST<C,SC |
| Nasal inner | 339.8 ± 2.26 | 332.1 ± 1.07 | 330.7 ± 1.39 | 335.1 ± 1.68 | 333.1 ± 3.86 | .017 |
| Superior inner | 338.4 ± 2.23 | 331.4 ± 1.13 | 329.5 ± 1.55 | 334.8 ± 1.60 | 333.7 ± 3.32 | .017 |
| Temporal inner | 325.0 ± 2.08 | 313.3 ± 1.20 | 311.6 ± 1.58 | 315.8 ± 2.12 | 316.7 ± 3.43 | <.001 SS<SC, ST |
| Inferior inner | 335.9 ± 2.30 | 328.6 ± 1.11 | 327.7 ± 1.47 | 330.1 ± 1.76 | 329.9 ± 3.82 | .08 |
| Nasal outer | 310.2 ± 2.08 | 308.3 ± 0.93 | 308.5 ± 1.16 | 309.2 ± 1.74 | 305.3 ± 3.19 | .559 |
| Superior outer | 294.6 ± 1.88 | 292.7 ± 0.89 | 292.4 ± 1.18 | 294.1 ± 1.55 | 291.3 ± 2.67 | .631 |
| Temporal outer | 281.7 ± 1.78 | 273.1 ± 1.28 | 272.3 ± 1.84 | 273.4 ± 1.92 | 276.3 ± 2.47 | .061 |
| Inferior outer | 287.1 ± 1.89 | 284.5 ± 0.90 | 286.1 ± 1.11 | 282.1 ± 1.66 | 281.7 ± 3.04 | .093 |
ANOVA, analysis of variance; SDOCT, spectral domain optical coherence tomography.
*
P values <.006 (ie, 0.05/9) are considered significant based on Bonferroni correction and are in bold type.
ANOVA, analysis of variance; ETDRS, Early Treatment Diabetic Retinopathy Study; Hgb, hemoglobin; SC, sickle cell Hgb SC subtype; SDOCT, spectral domain optical coherence tomography; SS, sickle cell Hgb SS subtype; SThal, sickle cell Hgb SThal subtype.
*
P values <.006 (ie, 0.05/9) are considered significant based on Bonferroni correction and are in bold type.