Table 6.

Association between SDOCT subfield measurements of sickle cell eyes and systemic diseases or surgical procedures in sickle cell patients based on repeated-measures ANOVA^*

CATEGORY	No. of patients				ANOVA P values	Association between Systemic Condition and SDOCT Measurements (P values from repeated-measures ANOVA)
	Contro l N=39	SS N=161	SC N=68	S-Thal N=31
Systemic disease	N %	N %	N %	N %	SCD vs Control SCD only	CST	Nasal Inner	Supe rior Inner	Tem poral inner	Inferi or Inner	Nasal Oute r	Supe rior Oute r	Tem poral Oute r	Inferi or Oute r
Acute chest syndrome	0	81	19	10	<.001	.881	.072	.067	.391	.148	.579	.249	.867	.805
	0	50.3	27.9	31.3	<.003
Avascular necrosis of any joint	0	42	19	13	.001	.358	.028	.086	.015	.008	.017	.011	.323	.006
	0	26.0	27.9	40.6	.248
Pulmonary hypertension	0	37	5	1	<.001	.419	.185	.281	.59	.55	.065	.072	.048	.154
	0	23	7.4	3.1	.001
Stroke	0	36	4	1	<.001	.176	.056	.252	.023	.026	.05	.47	.161	.228
	0	22.4	5.9	3.1	.001
Kidney disease	0	35	4	1	<.001	.8	.061	.077	.308	.124	.017	.014	.152	.072
	0	21.7	5.9	3.1	.001
Hypertension	12	27	22	5	.025	.045	<.001	<.001	<.001	<.001	<.001	<.001	<.001	<.001
	30.8	16.8	32.4	15.6	.022
Avascular necrosis of the hip joint	0	17	13	5	.023	.035	.4	.993	.269	.263	.877	.947	.857	.453
	0	10.6	19.1	15.6	.205
Liver disease	2	17	1	0	.026	.004	.567	.682	.885	.65	.227	.382	.575	.737
	5.1	10.6	1.5	0	.012
Pulmonary embolism	0	15	5	3	.262	<.001	.011	.014	.06	.046	.042	.309	.971	.084
	0	9.3	7.4	9.4	.885
Deep venous thrombosis	0	15	3	1	.11	. 0 01	<.001	<.001	<.001	.003	.001	.003	.01	.026
	0	9.3	4.4	3.1	.268
Seizure disorder	1	15	2	0	.068	. 3 2 7	.062	.002	.13	.035	.021	.001	.003	.002
	2.6	9.3	2.9	0	.057
Gallstones	0	13	2	3	.139	. 5 49	.119	.056	.021	.106	.004	.01	.156	.049
	0	8.1	2.9	9.4	.315
Diabetes mellitus	3	4	5	2	.283	.596	.197	.259	.486	.14	.266	.932	.871	.822
	7.7	2.5	7.4	6.3	.204
Surgical procedure	N %	N %	N %	N %	SCD vs. Control SCD only	CST	NASAL Inner	SUPERIOR inner	TEMPORAL Inner	INFERIOR INNER	NASAL Outer	SUPERIOR Outer	TEMPORAL Outer	INFERIOR OUTER
Cholecystectomy	2	76	16	6	<.001	.779	.908	.699	.752	.807	.417	.974	.613	.605
	5.1	47.2	23.5	18.8	<.001
Tonsillectomy	0	16	2	2	.069	. 7 14	.491	.863	.611	.896	.887	.805	.609	.637
	0	9.9	2.9	6.3	.182

ANOVA, analysis of variance; CST, central subfield thickness; SC, sickle cell hemoglobin SC subtype; SCD, sickle cell disease; SDOCT, spectral domain optical coherence tomography; SS, sickle cell hemoglobin SS subtype; SThal, sickle cell hemoglobin SThal subtype.

^*P values <.003 (ie, 0.05/15) for the associations are considered significant based on Bonferroni correction for group comparison. For the association between the systemic disease or surgical procedure and SDOCT subfield measurements, P values <.006 (ie, 0.05/9) are considered significant based on Bonferroni correction and are in bold type.