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Schematic diagram summarizing the thrombin generation and fibrin generation through the contact pathway or the extrinsic pathway (A). FXIa antibodies or increasing amounts of CTI delay fibrin generation for whole blood clotting under flow, while FXI-deficiency (hemophilia C, hemC) prevents fibrin formation (B, top). Fibrin generation during whole blood flow over collagen/high TF is not affected by FXIa inhibition, but requires intrinsic tenase (FIXa/FVIIIa) (C).
