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Measurement of thrombin-antithrombin (TAT) in the effluent allows calculation of thrombin flux per unit area per unit time for a collagen/TF surface. TAT is largely undetectable unless fibrin polymerization is inhibited with GPRP (A). The average thrombin flux for whole blood clotting in the presence of GPRP (B). Role of polyphosphate and FXIa in late stage thrombin generation at times > 500 s (C) (9).
