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. 2018 Jul 23;10:23. doi: 10.3389/fnsyn.2018.00023

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Copyright © 2018 Guerrier and Holcman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Calcium dynamic and vesicular release in the pre-synaptic terminal following three pulses. Comparison between slow unbinding from the Snare (k_U = 0.005 ms⁻¹) with the vesicle docking time τ_D = 0 ms (A), fast unbinding (k_U = 2 ms⁻¹) with τ_D = 50 ms (B), and fast unbinding with τ_D = ∞ (C) for 100 buffer molecules and 150 ms between two spikes. Up: Time course of free calcium (red) and buffered calcium (blue). Middle: Probability density function of the release times. Down: Paired Pulse Ratios (PPR), computed as the ratio of the number of fused vesicles during the first and the second spike.