Table 1.
Representative studies on the effects of various compounds on NRF2-mediated protection of gastrointestinal tract and liver against oxidative stresses
| Basic Study |
Clinical Study |
|||||
|---|---|---|---|---|---|---|
| In vitro | In vivo | Observational study | Intervention study | |||
| Isothiocyanates | Sulforaphane | 28, 29 | 28, 29, 56 | 42 (Constipation) 56 (H. pylori-gastritis) | ||
| Alyl-isothicyanate | 60 | 61 | ||||
| Polyphenols | Curcumin | 64, 65 | 66 (IBS), 67 (UC) | |||
| Catechin | 69 | 69, 70 | 71, 72, 73 | |||
| Quercetin | 76 | 77 | 78, 79 | |||
| Resveratrol | 81, 82 | 83 | 85 (UC) | |||
| Carotenoids | Lycopene | 87 | 88, 89 | |||
| Astaxanthin | 93, 95 | 93 | 98 (FD) | |||
| Drugs | Lansoprazole | 100, 101 | 102 (No effect), 103 | |||
| UDCA | 104 | 105 | 106 (Barret esophagus) | |||
| Sofalcon | 107 | 108 | 109 (Gastric uler) | |||
| Hormones | Ghrelin | 112, 113, 114, 115, 116 | 117 (Diabetic gastroparesis) | |||
| Melatonin | 119 | 120 | 121 (GERD), 122 (IBS) 123 (UC) | |||
Corresponding reference numbers in this paper are indicated in the Table. IBS, irriable bowel syndrome; UC, ulcerative colitis; GERD, gastroesophageal reflux disease; FD, functional dyspepsia.