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. 2018 Jul 12;7(14):e005171. doi: 10.1161/JAHA.116.005171

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Gastrin attenuated I/R‐induced cardiac injury in a Langendorff‐perfused system. A and B, Coronary effluent was collected at the end of reperfusion, and total cTnI (A) and LDH (B) concentrations were measured. *P<0.05 vs I/R, Student t test, n=6 per group. C and D, Apoptosis of cardiomyocytes was determined by TUNEL (terminal deoxynucleotidyl transferase dUTP nick‐end labeling) assay (C) and caspase 3 activity (D). E, Infarct size was determined by triphenyltetrazolium chloride staining. *P<0.01 vs I/R, Student t test, n=12. cTnI indicates cardiac troponin I; DAPI, 4′,6‐diamidino‐2‐phenylindole; gastrin+I/R, intraperitoneal injection of gastrin before ischemia/reperfusion; I/R indicates ischemia/reperfusion; LDH, lactate dehydrogenase; LV, left ventricle.