Table 16.
Risk Prediction Models With Added Biomarkers, Adjusting for the STS Model, at 5‐Year Mortality
| Prediction Models (Model ROC [95% CI]) | |||||||
|---|---|---|---|---|---|---|---|
| STS Model | STS+NT‐Pro BNP | STS+ST2 | STS+Gal3 | STS+Gal3+NT‐ProBNP | STS+ST2+NT‐ProBNP | STS+ST2+NT‐ProBNP+Gal3 | |
| Median | 0.69 (0.65–0.73) | 0.73 (0.70–0.77) | 0.71 (0.67–0.75) | 0.71 (0.67–0.75) | 0.74 (0.71–0.78) | 0.74 (0.70–0.78) | 0.75 (0.72–0.79) |
| P valuea | ··· | 0.001 | 0.021 | 0.045 | 0.000 | 0.000 | 0.000 |
| Tercile | 0.69 (0.65–0.73) | 0.74 (0.70–0.77) | 0.72 (0.68–0.75) | 0.71 (0.68–0.75) | 0.75 (0.72–0.78) | 0.75 (0.71–0.78) | 0.76 (0.72–0.79) |
| P valuea | ··· | 0.001 | 0.025 | 0.019 | 0.000 | 0.000 | 0.000 |
CI indicates confidence interval; Gal3, Galectin‐3; NT‐ProBNP, N terminal Pro b‐type natriuretic peptide; ROC; receiver operator characteristic; STS, Society of Thoracic Surgeons.
Model corrects for age, sex, body surface area, atrial fibrillation, last preoperative serum creatinine, presence of diabetes mellitus, ejection fraction <40%, hypertension, preoperative intra‐aortic balloon pump use, prior myocardial infarction, presence of any vascular disease, unstable angina, renal failure, chronic obstructive pulmonary disease, left main stenosis >50%, prior coronary artery bypass graft, prior percutaneous coronary intervention, date of operation, and urgent and emergent priority.