Skip to main content
. 2018 Jul 9;7(14):e009289. doi: 10.1161/JAHA.118.009289

Figure 2.

Figure 2

D7‐Des expression results in cardiac hypertrophy and fibrosis. A, Representative micrographs of Masson's trichrome‐stained LV myocardium and quantification of the cardiac fibrosis in Ntg and D7‐Des Tg hearts (n=5 mice per group). B, Representative micrographs of Sirius Red–stained LV myocardium and quantification of the myocardial collagen deposition in Ntg and D7‐Des Tg hearts (n=5 mice per group). C, Representative Western blot and densitometric quantification showing significantly increased expression of periostin in D7‐Des Tg hearts (n=5 mice per group). D, Heart‐weight‐to‐body‐weight ratios (HW/BW) showing LV hypertrophy in the D7‐Des Tg hearts (n≥6 or more mice per group). Bars represent mean±SEM. P values were determined by Tukey's post hoc test. Scale bars: 50 μm. D7‐Des Tg indicates mutant desmin transgenic mouse; LV, left ventricular; Ntg, non‐transgenic.