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. 2018 Jul 9;7(14):e009289. doi: 10.1161/JAHA.118.009289

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Aberrant mitochondrial fission and altered expression of fission regulatory proteins in D7‐Des Tg hearts. A, Representative transmission electron micrographs of hearts from D7‐Des Tg mice (Scale bars: 2 μm). B, Relative mtDNA content expressed compared with total genomic DNA (nDNA) in hearts of D7‐Des Tg was significantly increased compared with Ntg. Representative Western blot and densitometric quantification of the (C) whole cell fraction and (D) mitochondrial fraction showing expression of mitochondrial dynamic regulatory proteins in the D7‐Des Tg hearts: Drp1, pDrp1 (Ser 616), Fis 1, OPA1, OMA1, MFN2, Mff, Tom20, Tim23, and PGC1α. Ponceau S protein staining of the transfer membrane confirmed approximately equal loading across the gel. Bars represent mean±SEM. n=6 mice per group. P values were determined by Tukey's post hoc test. D7‐Des Tg indicates mutant desmin transgenic mouse; mtDNA, mitochondrial DNA; NS, not significant; Ntg, non‐transgenic.