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. 2018 Jul 9;7(14):e009289. doi: 10.1161/JAHA.118.009289

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Suppression of mitochondrial respiration in D7‐Des Tg mice hearts. A, Mitochondrial oxygen consumption rate (OCR) profiles in isolated mitochondria from 6‐month‐old Ntg and D7‐Des Tg hearts. Arrow indicates the sequential addition of oligomycin (1 μmol/L), FCCP (4 μmol/L), and rotenone (0.5 μmol/L) plus antimycin A (0.5 μmol/L). OCR profiles are expressed as pmol O₂/min per μg of protein. Graph shows OCR under (B) baseline as well as with the addition of (C) oligomycin, (D) FCCP, and (E) rotenone plus antimycin A. Key parameters of mitochondrial function, including (F) reserve capacity, (G) ATP turnover, and (H) maximal respiration were significantly decreased in D7‐Des Tg mice. n=3 mice per group. Boxes represent interquartile ranges, lines represent medians, whiskers represent ranges, and P values were determined by Kruskal–Wallis test. D7‐Des Tg indicates mutant desmin transgenic mouse; FCCP, carbonyl cyanide‐p‐trifluoromethoxy‐phenylhydrazone; Ntg, non‐transgenic.