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. 2018 Jul 9;7(14):e009289. doi: 10.1161/JAHA.118.009289

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Impaired OXPHOS protein expression and ATP content in the D7‐Des Tg hearts. A, Representative Western blot showing expression of Complex I, Complex II, Complex III, Complex V, and PDH complex protein derived from the mitochondrial fractions isolated from 6‐month‐old D7‐Des Tg hearts. Ponceau S protein stain of the transfer membrane was used to confirm approximately equal loading. Actin was used as a whole cell lysate and COX IV as a mitochondrial marker to indicate the purity of the fractionation. B, Densitometric quantification of OXPHOS complex and PDH complex protein. C, Mitochondrial and whole cellular ATP content in the D7‐Des Tg hearts. n=3 mice per group. Boxes represent interquartile ranges, lines represent medians, whiskers represent ranges, and P values were determined by Kruskal–Wallis test. D7‐Des Tg indicates mutant desmin transgenic mouse; NS, not significant; Ntg, non‐transgenic; PDH, pyruvate dehydrogenase.